Rompe el Silencio, funded by the Office of Women’s Health, sought to reduce the risk of HIV infection among U.S. Latinas by creating and strengthening an HIV/AIDS prevention intervention targeting Latinas and their families throughout the lifespan. This culturally based intervention was designed to help Latinas in East Los Angeles to decrease barriers to HIV/AIDS communication within the family and across generations. The intervention included discussions between mothers and daughters, and activities conducted in a culturally appropriate way. Findings suggest Rompe el Silencio was effective at increasing open discussions about sex, increasing comfort level with communication, and increasing HIV knowledge.